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Updated: Jun 18, 2026

Time-dependent Increase in the Network Response to the Stimulation of Neuronal Cell Cultures on Micro-electrode Arrays
Published on: May 29, 2017
Effect of stimulation on the input parameters of stochastic leaky integrate-and-fire neuronal model
Petr Lansky1, Pavel Sanda, Jufang He
1Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic. lansky@biomed.cas.cz
Abstract:
The Ornstein-Uhlenbeck neuronal model is specified by two types of parameters. One type corresponds to the properties of the neuronal membrane, whereas the second type (local average rate of the membrane depolarization and its variability) corresponds to the input of the neuron. In this article, we estimate the parameters of the second type from an intracellular record during neuronal firing caused by stimulation (audio signal). We compare the obtained estimates with those from the spontaneous part of the record. As predicted from the model construction, the values of the input parameters are larger for the periods when neuron is stimulated than for the spontaneous ones. Finally, the firing regimen of the model is checked. It is confirmed that the neuron is in the suprathreshold regimen during the stimulation.
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