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Related Experiment Video

Updated: Jun 18, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

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Published on: March 15, 2022

Preventing acute decrease in renal function induced by coronary angiography (PRECORD): a prospective randomized

Denis Angoulvant¹, Michel Cucherat, Gilles Rioufol

¹Service de cardiologie D, hôpital cardiovasculaire et pneumologique Louis-Pradel, groupement hospitalier Est, université Claude-Bernard Lyon-1, avenue Doyen-Lepine, Bron cedex, France.

Archives of Cardiovascular Diseases

|December 1, 2009

Summary

This summary is machine-generated.

Saline infusion does not significantly impact renal function after coronary angiography in patients without severe kidney disease. Standard oral hydration alone is sufficient for maintaining kidney health post-procedure.

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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

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Published on: February 2, 2021

Area of Science:

Cardiology
Nephrology
Radiology

Background:

Radiographic contrast agents can impair renal function, particularly in patients with pre-existing kidney disease.
Intravenous saline infusion is a known strategy to mitigate contrast-induced nephropathy.

Purpose of the Study:

To evaluate the efficacy of intravenous saline infusion in preserving renal function during and after coronary angiography.
To assess the impact of saline infusion on renal function in patients with mild-to-moderate chronic renal insufficiency.

Main Methods:

The Preventing Renal alteration in Coronary Disease (PRECORD) trial randomized 201 patients undergoing coronary angiography to receive either intravenous saline infusion or no additional hydration.
All patients received standard oral hydration. Renal function was assessed by calculating creatinine clearance at baseline and 24 hours post-procedure.
A consistent ionic low osmolar contrast agent (ioxaglate) was used for all participants.

Main Results:

No significant difference in the change of creatinine clearance was observed between the saline infusion group (-2.81 mL/min) and the control group (-4.09 mL/min) at 24 hours post-procedure (p=0.38).
Both groups experienced only a slight decrease in renal function, indicating that standard oral hydration was largely effective.

Conclusions:

Intravenous saline infusion initiated at the start of coronary angiography does not provide additional renal protection beyond standard oral hydration in patients with mild-to-moderate renal dysfunction.
Renal function remains only slightly altered 24 hours after coronary angiography when managed with standard oral hydration alone.