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Related Experiment Video

Updated: Jun 18, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

[Lymphangioleiomyomatosis].

Vincent Cottin1, Fabienne Archer, Chahéra Khouatra

  • 1Hospices civils de Lyon, Hôpital Louis Pradel, Service de pneumologie et centre de référence des maladies pulmonaires rares ; F-69677 Lyon Cedex, France. vincent.cottin@chu-lyon.fr

Presse Medicale (Paris, France : 1983)
|December 1, 2009
PubMed
Summary
This summary is machine-generated.

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Lymphangioleiomyomatosis (LAM) is a rare lung disease in women. Current treatments manage symptoms, but mTor inhibitors show promise, with lung transplantation considered for severe cases.

Area of Science:

  • Pulmonology
  • Oncology

Background:

  • Lymphangioleiomyomatosis (LAM) is a rare, progressive lung disease affecting women of reproductive age.
  • It presents with lung cysts, pneumothorax, and obstructive lung disorders, potentially leading to respiratory failure.

Purpose of the Study:

  • To outline recent international recommendations for diagnosing and treating LAM.
  • To summarize current therapeutic strategies and emerging treatments.

Main Methods:

  • Review of international diagnostic criteria for LAM, including non-biopsy approaches.
  • Summary of symptomatic management strategies for respiratory and renal complications.
  • Discussion of novel therapeutic agents and lung transplantation.

Main Results:

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Murine Dermal Lymphatic Endothelial Cell Isolation
05:52

Murine Dermal Lymphatic Endothelial Cell Isolation

Published on: July 21, 2023

Related Experiment Videos

Last Updated: Jun 18, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Murine Dermal Lymphatic Endothelial Cell Isolation
05:52

Murine Dermal Lymphatic Endothelial Cell Isolation

Published on: July 21, 2023

  • Diagnosis can be established using international criteria, reducing the need for lung biopsy.
  • Symptomatic treatments include bronchodilators, oxygen therapy, pleurodesis, and embolization for renal angiomyolipomas.
  • Hormone therapy is not recommended; mTor inhibitors are under investigation.

Conclusions:

  • International guidelines provide a framework for LAM diagnosis and management.
  • Current treatment focuses on symptom control, with promising research into mTor inhibitors.
  • Lung transplantation is a critical option for eligible patients with end-stage respiratory failure.