Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Inflammation01:38

Inflammation

Overview
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis and biological evaluation of branched N<sup>1</sup> functionalized lophine-pyrazole heptacycles as myeloperoxidase inhibitors and anti-inflammatory agents.

RSC medicinal chemistry·2026
Same author

Resveratrol protects against heatstroke and the complicated liver injury by inhibiting HSF1.

Food & function·2026
Same author

Filling the Gaps: Generating 4D Dense Cardiac Anatomy from Sparse CMR for Enhanced Tetralogy of Fallot Assessment.

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance·2026
Same author

Modeling Aleatoric Uncertainty in Cardiac MRI Segmentation: Probabilistic Detection and Contour Regression.

IEEE transactions on medical imaging·2026
Same author

AG-STDF: Anatomy-Guided ECG Spatiotemporal Dynamical Fusion for Screening Coronary Microvascular Dysfunction.

IEEE transactions on bio-medical engineering·2026
Same author

A bibliometric analysis of Kallmann syndrome: trends, hotspots, and future directions.

Orphanet journal of rare diseases·2026

Related Experiment Video

Updated: Jun 18, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Lipoic acid effects on established atherosclerosis.

Zhekang Ying1, Nisharahmed Kherada, Britten Farrar

  • 1Davis Heart Lung Research Institute, College of Medicine, and Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio 43210-1252, USA.

Life Sciences
|December 1, 2009
PubMed
Summary

Alpha-lipoic acid (LA) offers protection against atherosclerosis by reducing inflammation and improving vascular function. This study reveals LA

Related Experiment Videos

Last Updated: Jun 18, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Area of Science:

  • Cardiovascular Research
  • Nutritional Biochemistry
  • Immunology

Background:

  • Alpha-lipoic acid (LA) is a naturally occurring antioxidant with known anti-inflammatory properties.
  • Atherosclerosis is a chronic inflammatory disease characterized by plaque buildup in arteries.

Purpose of the Study:

  • To investigate the protective mechanisms of alpha-lipoic acid (LA) in a rabbit model of established atherosclerosis.
  • To elucidate how LA influences vascular function, immune cell migration, and inflammatory pathways relevant to atherosclerosis.

Main Methods:

  • Watanabe heritable hyperlipidemic (WHHL) rabbits were fed a high-cholesterol diet and treated with or without alpha-lipoic acid (LA).
  • Vascular function was assessed using myography, and T cell migration was evaluated via Boyden chamber assays.
  • NF-kappaB activation was measured using translocation and EMSA techniques.

Main Results:

  • Alpha-lipoic acid (LA) reduced atherosclerotic plaque size and inflammatory cell content in the aorta.
  • LA improved vascular reactivity, inhibited NF-kappaB activation, and decreased oxidative stress.
  • LA decreased T cell migration and adhesion to the endothelium, reducing ICAM and CD62L expression.

Conclusions:

  • Alpha-lipoic acid (LA) demonstrates therapeutic potential in established atherosclerosis.
  • LA exerts protective effects by modulating vascular function, reducing inflammation, and inhibiting immune cell infiltration.