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Microbes and Other Elemental Cycles01:24

Microbes and Other Elemental Cycles

Microbial activity plays a pivotal role in the biogeochemical cycling of iron and manganese, especially at the redox gradients characteristic of stratified aquatic environments. These cycles are driven by microbial transformations between oxidized and reduced forms of the metals, allowing organisms to exploit them for metabolic energy and structural purposes.Iron Cycling Across Redox GradientsIn neutral, oxygen-rich surface waters, iron is predominantly found in its oxidized, insoluble ferric...
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Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
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Updated: Jun 18, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

How iron controls iron.

Lukas C Kühn1

  • 1Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC - Swiss Institute for Experimental Cancer Research, 1015 Lausanne, Switzerland. lukas.kuehn@epfl.ch

Cell Metabolism
|December 1, 2009
PubMed
Summary
This summary is machine-generated.

Cells control iron levels using iron-regulatory proteins (IRPs). Recent studies reveal how cells adjust the activity of IRP2, a key protein in iron regulation.

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Electrophoretic Mobility Shift Assay (EMSA) for the Study of RNA-Protein Interactions: The IRE/IRP Example

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Related Experiment Videos

Last Updated: Jun 18, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

A Colorimetric Method for Measuring Iron Content in Plants
07:12

A Colorimetric Method for Measuring Iron Content in Plants

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Electrophoretic Mobility Shift Assay (EMSA) for the Study of RNA-Protein Interactions: The IRE/IRP Example
12:44

Electrophoretic Mobility Shift Assay (EMSA) for the Study of RNA-Protein Interactions: The IRE/IRP Example

Published on: December 3, 2014

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Cells maintain iron homeostasis through posttranscriptional regulation of proteins involved in iron uptake and storage.
  • This regulation relies on the RNA-binding activity of iron-regulatory proteins (IRPs), specifically IRP1 and IRP2.

Purpose of the Study:

  • To elucidate the mechanisms by which cells adjust the activity of IRP2.
  • To provide insights into the intricate cellular processes governing iron homeostasis.

Main Methods:

  • The studies involved analyzing the activity and regulation of IRP2 in cellular models.
  • Specific molecular and biochemical techniques were employed to investigate protein interactions and function.

Main Results:

  • The research identified key pathways controlling IRP2 activity.
  • These findings shed light on how cells dynamically manage iron levels.

Conclusions:

  • Understanding IRP2 regulation is crucial for comprehending cellular iron metabolism.
  • These discoveries offer potential targets for therapeutic interventions related to iron dysregulation.