Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel Use of Normothermic Machine Perfusion of the Liver: A Strategy to Mitigate Unexpected Clinical Events.

Transplantation·2020
Same author

Hypocapnia Alone Fails to Provoke Important Electrocardiogram Changes in Coronary Artery Diseased Patients.

Frontiers in physiology·2020
Same author

Multicentre analysis of current strategies and outcomes in open aortic arch surgery: heterogeneity is still an issue.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2016
Same author

Open aortic arch replacement in high-risk patients: the gold standard.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2015
Same author

Short-term intravenous sodium nitrite infusion improves cardiac and pulmonary hemodynamics in heart failure patients.

Circulation. Heart failure·2015
Same author

Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans.

British journal of pharmacology·2015

Related Experiment Video

Updated: Jun 18, 2026

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
04:09

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter

Published on: September 20, 2024

Thyroid hormone in cardiac surgery.

Aaron M Ranasinghe1, Robert S Bonser

  • 1University of Birmingham, Cardiovascular Medicine, School of Clinical and Experimental Medicine, Birmingham B15 2TT, UK. a.m.ranasinghe@bham.ac.uk

Vascular Pharmacology
|December 1, 2009
PubMed
Summary
This summary is machine-generated.

This review examines thyroid hormone supplementation for non-thyroidal illness syndrome after cardiac surgery. It discusses potential benefits and trial results in adult and pediatric patients, and brain-dead organ donors.

More Related Videos

Mixed Reality Assisted Radical Endoscopic Thyroidectomy
08:06

Mixed Reality Assisted Radical Endoscopic Thyroidectomy

Published on: January 31, 2025

Related Experiment Videos

Last Updated: Jun 18, 2026

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
04:09

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter

Published on: September 20, 2024

Mixed Reality Assisted Radical Endoscopic Thyroidectomy
08:06

Mixed Reality Assisted Radical Endoscopic Thyroidectomy

Published on: January 31, 2025

Area of Science:

  • Endocrinology
  • Cardiovascular Surgery
  • Critical Care Medicine

Background:

  • Thyroid hormone influences cardiovascular function via genomic and non-genomic pathways.
  • Non-thyroidal illness syndrome (NTIS), or euthyroid sick syndrome, is a common post-operative stress response after cardiac surgery.
  • The efficacy of acute thyroid hormone supplementation for NTIS in this context is debated.

Purpose of the Study:

  • To review the potential benefits of thyroid hormone supplementation in patients undergoing cardiac surgery.
  • To analyze trial data on thyroid hormone supplementation in adult and pediatric cardiac surgical populations.
  • To explore its role in optimizing cardiac donors from brain-dead individuals.

Main Methods:

  • Literature review of clinical trials and relevant studies.
  • Analysis of data concerning thyroid hormone levels and cardiovascular outcomes.
  • Synthesis of evidence regarding supplementation strategies.

Main Results:

  • Evidence regarding the benefits of thyroid hormone supplementation for NTIS post-cardiac surgery remains inconclusive.
  • Studies in adult and pediatric populations show varied outcomes.
  • Potential application in brain-dead organ donors requires further investigation.

Conclusions:

  • The use of thyroid hormone supplementation for NTIS following cardiac surgery requires careful consideration due to conflicting evidence.
  • Further research is needed to establish clear guidelines for its application in specific patient groups and organ donation settings.