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Updated: Jun 18, 2026

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
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Accelerated partial breast irradiation: initial experience with the Intrabeam System.

R L Elliott1, M DeLand, J F Head

  • 1Elliott, Elliott, Head Breast Cancer Research and Treatment Center, Baton Rouge, LA 70816, USA.

Surgical Oncology
|December 1, 2009
PubMed
Summary
This summary is machine-generated.

Intraoperative radiotherapy (IORT) offers excellent local control for breast cancer patients, showing no failures in a recent study. This accelerated partial breast irradiation technique is safe, effective, and well-tolerated in the community setting.

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Last Updated: Jun 18, 2026

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Published on: March 11, 2021

Area of Science:

  • Oncology
  • Radiotherapy
  • Surgical Oncology

Background:

  • Breast conserving surgery (BCS) failure often occurs at the primary tumor site.
  • Accelerated partial breast irradiation (APBI) is of interest for improved local control.
  • Targeting the tumor bed directly may enhance outcomes.

Purpose of the Study:

  • To evaluate the feasibility and outcomes of intraoperative radiotherapy (IORT) using the Intrabeam System.
  • To assess local control, cosmetic results, and complications of IORT in breast cancer patients.

Main Methods:

  • Patients >50 years with invasive ductal carcinoma underwent tumor excision.
  • Preoperative and intraoperative ultrasound ensured adequate margins.
  • Intraoperative radiotherapy (IORT) delivered to the tumor bed using the Intrabeam System.

Main Results:

  • 67 patients underwent IORT; 61 with primary surgery, 6 after re-exploration.
  • No serious surgical or radiation complications were reported.
  • Excellent cosmetic results and no local failures observed to date.

Conclusions:

  • Intraoperative radiotherapy (IORT) with the Intrabeam System is a feasible and safe option for breast cancer treatment.
  • The technique demonstrates good cosmetic outcomes, high patient acceptance, and effective local control.
  • IORT is practical for community settings, serving as a boost or primary treatment.