Related Experiment Video
Updated: Jun 18, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Towards development of selective and reversible pyrazoline based MAO-inhibitors: Synthesis, biological evaluation and
Anasuya Sahoo1, Samiye Yabanoglu, Barij N Sinha
1Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835 215, India.
Abstract:
Ten novel 3,5-diaryl pyrazolines were synthesized and investigated for their monoamine oxidase (MAO) inhibitory property. All the molecules were found to be reversible and selective inhibitor for either one of the isoform (MAO-A or MAO-B). Further insights in the theoretical evaluation of the possible interactions between the compounds and monoamine oxidases (MAO-A or MAO-B) have been developed through docking studies. The theoretical values are in congruence with their experimental values.
Related Concept Videos
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
Drug Discovery: Overview

