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Related Experiment Video

Updated: Jun 18, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Real-time three-dimensional echocardiography in evaluating Libman-Sacks vegetations.

Sotiris C Plastiras¹, Constantinos A Pamboucas, Maria Tektonidou

¹Department of Clinical Therapeutics, Echocardiography Unit, University of Athens Medical School, Alexandra Hospital, 80 Vasilisis Sofias Ave. & Lourou St., Athens, Greece. splastiras@vodafone.net.gr

European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology

|December 1, 2009

Summary

Libman-Sacks endocarditis involves sterile vegetations, often affecting the mitral valve in systemic lupus erythematosus patients. Real-time 3D echocardiography aids in accurately assessing vegetation size, influencing treatment decisions.

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Area of Science:

Cardiology
Rheumatology
Medical Imaging

Background:

Libman-Sacks endocarditis, identified in 1924, presents as sterile, fibrofibrinous vegetations on the endocardial surface.
It most frequently affects the mitral and aortic valves, with rare involvement of the tricuspid and pulmonary valves.
Vegetations occur in about 10% of systemic lupus erythematosus (SLE) patients, detected via transesophageal echocardiography (TTE).

Observation:

Libman-Sacks vegetations show variable associations with SLE duration, disease activity, anticardiolipin antibodies, and antiphospholipid syndrome.
Transthoracic echocardiogram (TTE) is established for evaluating these vegetations.
Accurate vegetation size estimation is crucial for guiding therapeutic interventions.

Findings:

Real-time 3D (RT3D) echocardiography offers enhanced capabilities for evaluating Libman-Sacks vegetation size.
RT3D imaging may strengthen the diagnostic role of traditional echocardiographic methods.
This study highlights the utility of RT3D echocardiography in assessing vegetation dimensions.

Implications:

Improved assessment of vegetation size can refine treatment strategies for Libman-Sacks endocarditis.
RT3D echocardiography may become a key tool in managing cardiac manifestations of SLE.
Enhanced imaging accuracy can lead to better patient outcomes in Libman-Sacks endocarditis.