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Related Experiment Video

Updated: Jun 18, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Published on: June 28, 2019

Coronary flow reserve evaluation: basics, techniques and clinical applications.

R De Rosa¹, R Piccolo, S Cassese

¹Clinical Medicine Department, Federico II University Hospital, Naples, Italy.

Minerva Cardioangiologica

|December 1, 2009

Summary

Fractional flow reserve (FFR) is a reliable measure of coronary stenosis severity, offering crucial functional insights for diagnosing and managing coronary artery disease and guiding interventions.

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Last Updated: Jun 18, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

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Published on: June 28, 2019

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Published on: August 25, 2023

Area of Science:

Cardiovascular Physiology
Interventional Cardiology

Background:

Coronary flow reserve (CFR) provides vital information on coronary stenosis severity.
Fractional flow reserve (FFR) measured with a pressure wire is the current gold standard for CFR assessment.

Purpose of the Study:

To review the current literature on CFR quantification and clinical validation.
To highlight the current and future clinical applications of FFR.

Main Methods:

Review of existing scientific literature on FFR.
Analysis of FFR's diagnostic accuracy, reproducibility, and clinical outcomes association.

Main Results:

FFR demonstrates high lesion specificity, low variability, and a defined cut-off range (0.75-0.80).
FFR is reproducible, feasible, and associated with patient outcomes and successful percutaneous coronary intervention.
Abnormal FFR can indicate diffuse atherosclerosis even without significant localized stenoses.

Conclusions:

FFR provides crucial functional information that complements morphological findings.
FFR offers a cheaper, easier, and more accessible method for assessing coronary artery disease severity.
FFR has established clinical utility and promising future applications in cardiology.