Related Experiment Video

Updated: Jun 18, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

The role of probiotics in allergic diseases

Sonia Michail1

  • 1Department of Gastroenterology and Nutrition, Wright State University Boonshoft School of Medicine Dayton Children's Medical Center, Dayton, Ohio 45404, USA. sonia.michail@wright.edu

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
|December 1, 2009
PubMed

Insights

Probiotics show limited benefits for pediatric atopic dermatitis and allergic rhinitis, with no current role in treating pediatric asthma. Further research is needed to clarify their role in allergic disorders.

Area of Science:

  • Pediatric Allergy and Immunology
  • Microbiome Research
  • Immunomodulation

Background:

  • Allergic disorders are prevalent in children, with environmental factors and gut microbiota implicated.
  • An aberrant gut microbiota may shift the T-helper 1 (Th1)/Th2 balance towards a Th2 response, exacerbating allergies.
  • Probiotics are investigated for their potential to modulate the immune system towards a Th1 response.

Purpose of the Study:

  • To review the current evidence on the role of probiotics in pediatric allergic disorders.
  • To evaluate the efficacy of probiotics in atopic dermatitis, allergic rhinitis, and bronchial asthma.
  • To identify areas for future research in probiotic therapy for pediatric allergies.

Main Methods:

  • Systematic review of in vitro studies and human clinical trials.
  • Analysis of data on probiotic use in prevention and treatment of pediatric allergic conditions.
  • Assessment of immune system modulation by probiotics.

Main Results:

  • In vitro studies suggest a potential role for probiotics in managing allergic conditions.
  • Human trials show limited preventive and therapeutic benefits of probiotics for pediatric atopic dermatitis.
  • Evidence for probiotic efficacy in allergic rhinitis is less robust; no current role in pediatric asthma treatment.

Conclusions:

  • Probiotic therapy demonstrates limited efficacy in pediatric allergic disorders.
  • Further high-quality studies are essential to define the precise role of probiotics.
  • The gut microbiota's influence on pediatric allergies warrants continued investigation.

More Related Videos

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products12:40

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Published on: April 6, 2015

Related Concept Videos

Probiotics01:22

Probiotics

Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
Allergic Reactions02:06

Allergic Reactions

Overview
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...