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Low-molecular-weight heparin use in a case of noncardiogenic multifocal perinatal thromboembolic stroke

Matthew A Saxonhouse1, Dan Tarquinio, Paul R Carney

  • 1Division of Neonatology, Department of Pediatrics, University of Florida, Gainesville, FL 32610-0296, USA.

Advances in Hematology
|December 1, 2009
PubMed

A full-term neonate suffered multifocal cerebral infarctions due to multiple large vessel thrombi. Thrombophilia and cardiovascular assessments were negative, but due to the severity of the lesions and the concern for expansion of the thrombi or future embolic events, treatment with low-molecular-weight heparin (LMWH) was initiated. No complications from treatment were experienced. We present this severe case in order to highlight difficult management decisions for newborns with multifocal perinatal thromboembolic stroke and to stress the need for further practice guidelines and research in this area.

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