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Updated: Feb 15, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
Published on: May 30, 2025
Acitretin-associated erectile dysfunction: a case report
Marco Rossi1, Michele Pellegrino
1Department of Pharmacology Giorgio Segre, University of Siena, Strada delle Scotte 6, 53100 Siena, Italy. marcorss@alice.it
Introduction:
Two cases of impotence following a treatment with etretinate have been reported in the literature. Acitretin is the principal active metabolite of etretinate. We report a case of erectile dysfunction associated with the use of acitretin.
Case Presentation:
A 39-year-old Caucasian man referred his incapacity to reach and maintain a penile erection during a course of acitretin for the treatment of a severe form of psoriasis. Physical examination, laboratory findings and psychological analysis did not reveal any abnormalities. Two weeks after the withdrawal of acitretin, the patient reported a normalization of his sexual activity.
Conclusion:
Retinoids have been associated with male reproductive system dysfunctions in human and animal studies. Clinicians should be aware of the possibility of acitretin-induced erectile dysfunction.
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