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UV spectrophotometric method for the identification and solubility determination of nevirapine
N Stieger1, W Liebenberg, J C Wessels
1North-West University, Faculty of Health Sciences, Potchefstroom, South-Africa. nicole.stieger@nwu.ac.za
Die Pharmazie
|December 2, 2009
Abstract:
An UV spectrophotometric method was developed for the quantitative determination of nevirapine in water, methanol and 0.1 N HCl. It was found that qualitative determination is also possible, due to a peak-shift observed with 0.1 N HCl. The solubility at 37 degrees C, for both the anhydrous and Hemihydrated forms of nevirapine, was determined in each of the three solvents.
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