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[Expression of EMS1 protein and its clinical significance in laryngeal carcinoma]
Lianhe Li1, Zhuoli Yue, Xiuling Feng
1Department of Otolaryngology, Affiliated Hospital of Chengde Medical Institute, Chengde, 067000, China. llh186@163.com
Objective:
To investigate the expression of EMS1 in laryngeal carcinoma and its clinical significance.
Method:
The expression of EMS1 protein was measured in 40 samples of, 40 samples of para carcinoma tissues (which were near to cutting margin of laryngeal carcinoma tissue over 0.5 cm), and 20 samples of normal laryngeal mucosa as controls by Flow Cytometer (Epics-XL II).
Result:
The quantity and percentage of EMS1 protein expression in laryngeal carcinoma tissues was significantly higher than those in para carcinoma and in normal laryngeal mucosa tissues respectively (P<0.05). There was no significant expression difference between the para carcinoma tissues and normal laryngeal mucosa tissues. There were positive correlation between the expressions of EMS1 protein and metastasis, pathological grade and clinical stage in laryngeal carcinoma. But there were not relationship with patients' clinical classification, tumor size, smoking history, age and sex.
Conclusion:
The high expression of EMS1 may contribute to the carcinogenesis and development of laryngeal carcinoma. The expression of EMS1 protein is an important index of judging differentiation, infiltration, metastasis and staging of laryngeal carcinoma.