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An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
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[Microflora of the small intestine in patients with perforating duodenal ulcers]

S I Peregudov, G I Sinenchenko, A A Kurygin

    Vestnik Khirurgii Imeni I. I. Grekova
    |December 2, 2009
    PubMed

    Insights

    Perforating duodenal ulcers cause small intestine bacterial overgrowth, primarily by Enterobacteriaceae and aerobic Gram-positive bacilli. These common gut bacteria are key infectious agents in this condition.

    Area of Science:

    • Gastroenterology
    • Microbiology
    • Surgical Infections

    Background:

    • Peritonitis from perforating duodenal ulcers involves bacterial translocation.
    • Small intestine bacterial overgrowth (SIBO) is a known complication, but its specific profile in this context is less understood.

    Purpose of the Study:

    • To characterize the bacterial species involved in small intestine colonization during the toxic phase of peritonitis secondary to perforating duodenal ulcers.
    • To compare the microbial profile with other forms of intra-abdominal infection.

    Main Methods:

    • Analysis of bacterial populations in the small intestine of patients with perforating duodenal ulcers.
    • Quantitative assessment of bacterial species and families.

    Main Results:

    • Significant bacterial colonization of the small intestine was observed, though less pronounced than in other intra-abdominal infections.
    • Enterobacteriaceae and aerobic Gram-positive bacilli showed the greatest quantitative increase.
    • Dominant etiological agents were bacterial species normally found in the upper intestine.

    Conclusions:

    • The microbial landscape in peritonitis from duodenal ulcers is characterized by overgrowth of common aerobic gut flora.
    • Strict anaerobic bacteria are less frequently implicated in the small intestine in this specific condition compared to other peritonitis etiologies.

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