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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

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Related Experiment Video

Updated: Jun 18, 2026

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

[Epigenetics and cancer].

Chunyang Xue1, Jianning Yu, Honglin Liu

  • 1College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi
|December 2, 2009
PubMed
Summary
This summary is machine-generated.

Epigenetic modifications regulate gene expression without altering DNA sequence. These reversible changes offer promising therapeutic strategies for cancer by reactivating silenced genes.

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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
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Published on: September 18, 2020

Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Context:

  • Epigenetic modifications, such as DNA methylation and histone modifications, play crucial roles in gene transcription.
  • These modifications are heritable yet potentially reversible, presenting therapeutic opportunities.

Purpose:

  • To review the research progress in epigenetic gene regulation.
  • To discuss proteins involved in reading epigenetic codes.
  • To comprehensively analyze the relationship between epigenetics and cancer.

Summary:

  • Epigenetic modifications influence gene transcription without changing the underlying DNA sequence.
  • Reversibility of epigenetic events opens avenues for cancer therapy.
  • Understanding epigenetic mechanisms is key to developing novel cancer treatments.

Impact:

  • Epigenetic therapies aim to "turn back on" silenced genes, offering a significant advancement in cancer treatment.
  • This review highlights the potential of targeting epigenetic modifications for oncological interventions.
  • The findings underscore the importance of epigenetics in cancer research and drug discovery.