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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

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Polylactide stereocomplex-based electrospun materials possessing surface with antibacterial and hemostatic

Mariya Spasova¹, Nevena Manolova, Dilyana Paneva

¹Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev str., bl. 103A, 1113 Sofia, Bulgaria.

Biomacromolecules

|December 2, 2009

Summary

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Novel fibrous materials made from stereocomplex poly(lactide) and PDMAEMA copolymers exhibit hemostatic and antibacterial properties. These advanced materials show potential for biomedical applications due to their unique surface chemistry and structure.

Area of Science:

Materials Science
Polymer Chemistry
Biomedical Engineering

Background:

High-molecular-weight poly(d- or l-)lactide (HMPDLA or HMPLLA) and diblock copolymers are key components in advanced material development.
Poly(N,N-dimethylamino-2-ethyl methacrylate) (PDMAEMA) blocks offer unique surface properties.
Stereocomplex formation in polylactide (PLA) enhances material properties.

Purpose of the Study:

To prepare novel stereocomplex fibrous materials using HMPDLA/HMPLLA and PLA-block-PDMAEMA or PDLA-block-PDMAEMA copolymers.
To characterize the structure, composition, and properties of the resulting fibers.
To evaluate the hemostatic and antibacterial potential of the developed fibrous materials.

Main Methods:

Solution electrospinning was employed to fabricate the fibrous materials.

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Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used to confirm stereocomplex formation.

X-ray photoelectron spectroscopy (XPS) analyzed the surface composition.

In vitro tests assessed hemostatic and antibacterial efficacy.

Main Results:

Fibers with mean diameters between 1400 and 1700 nm were successfully produced.
DSC and XRD confirmed the formation of PLA stereocomplex, with characteristic crystalline peaks after annealing.
XPS revealed a surface gradient enriched in PDMAEMA's tertiary amino groups.
The materials demonstrated significant hemostatic and antibacterial activities.

Conclusions:

Novel stereocomplex fibrous materials with tunable surface chemistry were successfully fabricated.
The presence of PDMAEMA blocks created a surface rich in amino groups, imparting beneficial properties.
These fibrous materials exhibit promising hemostatic and antibacterial characteristics for biomedical applications.