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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
Pharmacology and clinical use of voriconazole
George R Thompson1, James S Lewis
1University of Texas, Health Science Center at San Antonio, Division of Infectious Diseases, Department of Medicine, San Antonio, TX 78229-3900, USA. thompsong2@uthscsa.edu
Importance Of The Field:
Voriconazole is an extended-spectrum triazole developed specifically to target Aspergillus spp. and is now indicated as primary therapy in this circumstance. However, it has a broad spectrum of activity against both yeasts and molds and is also a viable treatment option in the treatment of other mycoses.
Areas Covered In This Review:
This review discusses the mechanism of action, the pharmacodynamics and pharmacokinetics and the most common mechanisms of resistance to this agent. An overview of therapeutic drug monitoring, drug-drug interactions and pivotal trials are also reviewed.
What The Reader Will Gain:
The reader will gain further knowledge of the unique aspects of voriconazole compared to other currently available antifungal agents.
Take Home Message:
Voriconazole offers distinct advantages over several other antifungals. The side effect profile of voriconazole is unique compared to other triazole agents. Concern for drug-drug interactions due to a frequently shared common metabolic pathway has prompted heightened interest in the use of therapeutic drug monitoring for concerns of toxicity, drug-drug interactions and in attempts to ensure efficacy. These aspects as well as a review of important clinical information pertaining to voriconazole are discussed here.
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