Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pneumothorax in AIDS.

K A Sepkowitz1, E E Telzak, J W Gold

  • 1Memorial Sloan-Kettering Cancer Center, New York, New York.

Annals of Internal Medicine
|March 15, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mycobacterium haemophilum infections in bone marrow transplant recipients.

Transplantation·1995
Same author

Patients' views of priority setting in health care: an interview survey in one practice.

BMJ (Clinical research ed.)·1995
Same author

Direct observations of surgical wound infections at a comprehensive cancer center.

Archives of surgery (Chicago, Ill. : 1960)·1995
Same author

Treatment of opportunistic infections in AIDS.

Lancet (London, England)·1995
Same author

A corporate needs assessment for the purchase of district nursing: a qualitative approach.

Public health·1995
Same author

Crouzon and Apert syndromes: intracranial volume measurements before and after cranio-orbital reshaping in childhood.

Plastic and reconstructive surgery·1995
Same journal

Correction to I.M. Matters News: Sleep medicine for seniors.

Annals of internal medicine·2026
Same journal

Adverse Events After Same-Day COVID-19 and Influenza Vaccination Versus Influenza Vaccination Alone : A Target Trial Emulation.

Annals of internal medicine·2026
Same journal

Leveraging Real-World Evidence to Inform Regulatory, Clinical, and Coverage Decisions Related to Glucagon-Like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026
Same journal

Methodological Approaches to Real-World Evidence Generation for Glucagon-like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026
Same journal

Weekly and Biweekly Treatment With Bofanglutide Versus Semaglutide in Chinese Patients With Type 2 Diabetes : A Phase 2b Randomized Clinical Trial.

Annals of internal medicine·2026
Same journal

Grappling with GLP-1 prescribing.

Annals of internal medicine·2026
See all related articles

Patients with acquired immunodeficiency syndrome (AIDS) who develop pneumothorax often have concurrent Pneumocystis pneumonia. Aerosol pentamidine prophylaxis is a significant risk factor for pneumothorax in these patients.

Area of Science:

  • Infectious Diseases
  • Pulmonology
  • Critical Care Medicine

Background:

  • Pneumothorax is a rare but serious complication in patients with acquired immunodeficiency syndrome (AIDS).
  • Identifying risk factors is crucial for managing and preventing pneumothorax in this vulnerable population.

Purpose of the Study:

  • To identify risk factors associated with the development of pneumothorax in patients diagnosed with AIDS.
  • To understand the clinical presentation and outcomes of pneumothorax in the context of AIDS.

Main Methods:

  • A prospective cohort study was conducted at a tertiary care center.
  • 1030 patients with AIDS were followed over a 10-year period.
  • 20 patients (2%) developed pneumothorax unrelated to trauma or procedures.

Related Experiment Videos

Main Results:

  • 19 out of 20 patients with pneumothorax had concurrent Pneumocystis carinii pneumonia.
  • Aerosol pentamidine prophylaxis (RR, 17.6) and a history of P. carinii pneumonia (RR, 14.5) were significant risk factors.
  • Aerosol pentamidine use remained a significant independent risk factor after stratification.

Conclusions:

  • Patients with AIDS, a history of P. carinii pneumonia, and receiving aerosol pentamidine prophylaxis are at the highest risk for pneumothorax.
  • Pneumocystis carinii pneumonia should be strongly considered in AIDS patients presenting with pneumothorax.
  • Despite the increased risk, the benefits of aerosol pentamidine prophylaxis outweigh the risk of pneumothorax.