Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Inflammation01:38

Inflammation

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The landscape of CAR T-cell therapy in the United States and China: A comparative analysis.

International journal of cancer·2018
Same author

A Novel Tb@Sr-MOF as Self-Calibrating Luminescent Sensor for Nutritional Antioxidant.

Nanomaterials (Basel, Switzerland)·2018
Same author

Association of human leukocyte antigen alleles and supertypes with immunogenicity of oral rotavirus vaccine given to infants in China.

Medicine·2018
Same author

ANXC7 Is a Mitochondrion-Localized Annexin Involved in Controlling Conidium Development and Oxidative Resistance in the Thermophilic Fungus <i>Thermomyces lanuginosus</i>.

Frontiers in microbiology·2018
Same author

High mobility group box-1 induces pro-inflammatory signaling in human nucleus pulposus cells via toll-like receptor 4-dependent pathway.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2018
Same author

Molecular investigation of "Candidatus Mycoplasma haemobos" in goats and sheep in central China.

Transboundary and emerging diseases·2018
Same journal

Cumulative Contents.

Biochimica et biophysica acta·2020
Same journal

Molecular Basis of Disease Cumulative Contents.

Biochimica et biophysica acta·2020
Same journal

General Subjects Cumulative Contents.

Biochimica et biophysica acta·2020
Same journal

Erratum to 'on the role of exchangeable hydrogen bonds for the kinetics of P680<sup>+·</sup> Q<sub>A</sub> <sup>-·</sup> formation and P680<sup>+·</sup> Pheo<sup>-·</sup> recombination in photosystem II' [Biochim. Biophys. Acta 1276 (1996) 35-44].

Biochimica et biophysica acta·2019
Same journal

Oligomeric state of the light-harvesting complexes B800-850 and B875 from purple bacterium Rubrivivax gelatinosus in detergent solution.

Biochimica et biophysica acta·2019
Same journal

Regulation of pigment content and enzyme activity in the cyanobacterium Nostoc sp. Mac grown in continuous light, a light-dark photoperiod, or darkness.

Biochimica et biophysica acta·2019
See all related articles

Related Experiment Video

Updated: Jun 18, 2026

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks
12:19

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks

Published on: November 10, 2016

Targeting HMGB1 in inflammation.

Huan Yang1, Kevin J Tracey

  • 1Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA. hyang@nshs.edu

Biochimica Et Biophysica Acta
|December 2, 2009
PubMed
Summary
This summary is machine-generated.

High mobility group box 1 (HMGB1) protein mediates inflammation in sterile and infection responses. Targeting HMGB1 shows protective effects in preclinical models of inflammation and injury, suggesting therapeutic potential.

Related Experiment Videos

Last Updated: Jun 18, 2026

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks
12:19

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks

Published on: November 10, 2016

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • High mobility group box 1 (HMGB1) is a conserved protein found in most cell types.
  • HMGB1 acts as a key mediator in both sterile and infection-associated inflammatory responses.
  • Elevated HMGB1 levels are observed in tissues and serum during sterile injury and infection.

Purpose of the Study:

  • To investigate the role of HMGB1 as a mediator of inflammation.
  • To evaluate the therapeutic potential of targeting HMGB1 in preclinical models of inflammatory diseases.

Main Methods:

  • Review of existing literature on HMGB1's function in inflammation.
  • Analysis of preclinical data from models including endotoxemia, sepsis, arthritis, and ischemia-reperfusion injury.

Main Results:

  • HMGB1 is both necessary and sufficient for mediating inflammation.
  • Antibodies and antagonists targeting HMGB1 demonstrated protective effects in various preclinical inflammatory disease models.
  • Successful targeting of HMGB1 offers therapeutic benefits in models of inflammation, infection, and ischemia-reperfusion injury.

Conclusions:

  • HMGB1 is a critical target for managing inflammatory conditions.
  • Understanding the biological mechanisms of HMGB1 action is crucial for therapeutic development.
  • Targeting HMGB1 holds promise for treating inflammation, infection, and ischemia-reperfusion induced injuries.