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Published on: February 15, 2016
Microwave assisted synthesis and antimicrobial activity of 2-quinoxalinone-3-hydrazone derivatives
Olayinka O Ajani1, Craig A Obafemi, Obinna C Nwinyi
1Chemistry Department, Covenant University, Canaanland, PMB 1023 Ota, Ogun State, Nigeria. wajanfresh@yahoo.com
Abstract:
A simple and efficient method has been developed for the synthesis of various 2-quinoxalinone-3-hydrazone derivatives using microwave irradiation technique. The series of 2-quinoxalinone-3-hydrazone derivatives synthesized, were structurally confirmed by analytical and spectral data and evaluated for their antimicrobial activities. The results showed that this skeletal framework exhibited marked potency as antimicrobial agents. The most active antibacterial agent was 3-{2-[1-(6-chloro-2-oxo-2H-chromen-3-yl)ethylidene]hydrazinyl}quinoxalin-2(1H)-one, 7 while 3-[2-(propan-2-ylidene)hydrazinyl]quinoxalin-2(1H)-one, 2 appeared to be the most active antifungal agent.

