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Modified Octopus Technique for Thoracoabdominal Aortic Aneurysm

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Diabetes and the abdominal aortic aneurysm.

S Shantikumar¹, R Ajjan, K E Porter

¹Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK.

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery

|December 2, 2009

Summary

Diabetes appears to protect against abdominal aortic aneurysms (AAAs). This review found a lower prevalence of diabetes in patients with AAAs compared to those without, suggesting a potential protective role. Further research is needed.

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Area of Science:

Cardiovascular Medicine
Endocrinology
Epidemiology

Background:

Abdominal aortic aneurysms (AAAs) are a significant cause of mortality.
The relationship between diabetes mellitus and AAA development is not fully understood.
Existing research presents conflicting findings on this association.

Purpose of the Study:

To systematically review and analyze the association between diabetes mellitus and abdominal aortic aneurysms (AAAs).
To explore potential mechanisms underlying any observed relationship.
To provide a pooled analysis of prevalence data.

Main Methods:

A systematic literature review was conducted using PubMed, EMBASE, and Cochrane databases up to September 2009.
Studies reporting prevalence data for diabetes in AAA patients and controls were identified.
A meta-analysis was performed on the collected prevalence data.

Main Results:

Eleven studies met the inclusion criteria.
Prevalence of diabetes in AAA patients ranged from 6% to 14%.
Prevalence of diabetes in control (non-AAA) groups ranged from 17% to 36%.
Pooled analysis indicated a significantly reduced rate of diabetes in individuals with AAA (OR 0.65, p<0.001).

Conclusions:

Current evidence suggests that diabetes mellitus may have a protective effect against the development of abdominal aortic aneurysms.
The underlying biological mechanisms for this protective association require further investigation.
Additional research is warranted to elucidate the relationship between diabetes and AAA.