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Renoprotective effect of rosuvastatin in DOCA-salt hypertensive rats

Eun Hui Bae1, In Jin Kim, Jeong Woo Park

  • 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju 501-757, Korea.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|December 2, 2009
PubMed
Abstract

Insights

Rosuvastatin treatment attenuated renal injury in deoxycorticosterone acetate-salt hypertensive rats by reducing inflammation and fibrosis. This study highlights rosuvastatin

Area of Science:

  • Nephrology
  • Pharmacology
  • Cardiovascular Medicine

Background:

  • Hypertension-induced end-organ damage is a significant clinical concern.
  • Statins, like rosuvastatin, exhibit pleiotropic effects beyond lipid-lowering.
  • Investigating rosuvastatin's impact on renal dysfunction in hypertension models is crucial.

Purpose of the Study:

  • To evaluate the renoprotective effects of rosuvastatin in deoxycorticosterone acetate-salt hypertensive (DSH) rats.
  • To determine rosuvastatin's influence on renal function, glomerulosclerosis, and tubulointerstitial fibrosis.

Main Methods:

  • Deoxycorticosterone acetate-salt hypertension was induced in unilaterally nephrectomized rats.
  • Rats received rosuvastatin (10 mg/kg/day) or a control diet.
  • Renal function, fibrosis markers, and inflammatory cytokine expression (TNF-α, IL-1β, IFN-γ, MCP1, ICAM-1, ET-1) were assessed.

Main Results:

  • Rosuvastatin treatment attenuated increased urinary albumin excretion and decreased creatinine clearance in DSH rats.
  • Histological analysis revealed reduced glomerulosclerosis and tubulointerstitial fibrosis with rosuvastatin.
  • Rosuvastatin significantly decreased the expression of pro-inflammatory cytokines and fibrotic markers (ED-1, TGF-β1, CTGF).

Conclusions:

  • Rosuvastatin effectively prevents the progression of renal injury in a DSH rat model.
  • The renoprotective mechanism involves significant anti-inflammatory and anti-fibrotic effects.
  • Rosuvastatin holds potential as a therapeutic agent for hypertensive renal damage.

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