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Using an α-Bungarotoxin Binding Site Tag to Study GABA A Receptor Membrane Localization and Trafficking
11:57

Using an α-Bungarotoxin Binding Site Tag to Study GABA A Receptor Membrane Localization and Trafficking

Published on: March 28, 2014

GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET.

Fraser J Moss1, P I Imoukhuede, Kimberly Scott

  • 1Division of Biology and 1,2 Program in Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA.

The Journal of General Physiology
|December 2, 2009
PubMed
Summary

Mouse gamma-aminobutyric acid (GABA) transporter mGAT1 assembly and trafficking were studied. Pixel-by-pixel analysis revealed three distinct mGAT1 forms: dimers, higher-order oligomers, and PDZ-interacting transporters linked to the cytoskeleton.

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