Related Experiment Video
Updated: Jun 18, 2026

07:56
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
Age comparisons of bone density and geometry in men
V D Sherk1, M Karabulut, M G Bemben
1Bone Density Research Laboratory, Department of Health and Exercise Science, University of Oklahoma, Norman, Oklahoma 73019, USA.
Journal of Musculoskeletal & Neuronal Interactions
|December 2, 2009
Summary
Younger men have denser tibia bone than older men. Body composition measurements from DXA and pQCT show age-dependent relationships, impacting bone health assessments.
Area of Science:
- Bone densitometry and body composition analysis.
- Gerontology and human physiology.
Background:
- Bone density and geometry change with age.
- Understanding these changes is crucial for assessing bone health and fracture risk.
Purpose of the Study:
- To compare tibia bone density and geometry in young versus middle-aged men.
- To investigate the relationship between body composition measures from DXA and pQCT across age groups.
Main Methods:
- Dual Energy X-ray Absorptiometry (DXA) for total body bone mineral density and composition.
- Peripheral Quantitative Computed Tomography (pQCT) for volumetric bone characteristics, muscle, and fat cross-sectional areas in the leg.
Main Results:
- Younger men were lighter with less fat mass than older men.
- Older men exhibited lower volumetric bone density (vBMD) in the tibia.
- Bone-free lean body mass predicted tibial bone area and content; muscle cross-sectional area was a stronger predictor of leg lean mass in older men.
Conclusions:
- Significant differences in tibia bone area and density exist between young and middle-aged men.
- The relationships between DXA- and pQCT-derived body composition variables are age-dependent, influencing interpretation.
More Related Videos
Related Concept Videos
Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Changes in the Appendicular Skeleton with Age
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Introduction to the Skeletal System
The skeletal system is the central framework of the body, consisting of different connective tissues: bones, cartilage, tendons, and ligaments.
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
Cartilage, a semi-rigid connective tissue found in regions such as...
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
Cartilage, a semi-rigid connective tissue found in regions such as...
Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Structure
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
Gross Anatomy of Bone
The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...

