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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
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Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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Structural covariance in the hallucinating brain: a voxel-based morphometry study.

Gemma Modinos1, Ans Vercammen, Andrea Mechelli

  • 1BCN Neuroimaging Center, Department of Neuroscience, University of Groningen, Groningen, the Netherlands. g.modinos@med.umcg.nl

Journal of Psychiatry & Neuroscience : JPN
|December 2, 2009
PubMed
Summary
This summary is machine-generated.

Auditory verbal hallucinations (AVHs) severity in schizophrenia is linked to altered brain structure. Specifically, grey matter in the left inferior frontal gyrus correlates with hallucination intensity, impacting frontotemporal networks.

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Area of Science:

  • Neuroimaging
  • Psychiatry
  • Neuroscience

Background:

  • Schizophrenia is associated with altered structural covariance in cortical regions.
  • The link between these brain alterations and specific psychotic symptoms, like auditory verbal hallucinations (AVHs), remains under-investigated.

Purpose of the Study:

  • To investigate the relationship between regional grey matter volumes, structural covariance, and the severity of auditory verbal hallucinations in patients with schizophrenia.
  • To examine how hallucination severity modulates brain structure and connectivity.

Main Methods:

  • Utilized optimized voxel-based morphometry on volumetric MRI data from 26 patients with medication-resistant AVHs.
  • Employed statistical inferences corrected for multiple comparisons at p < 0.05.

Main Results:

  • Found a positive correlation between grey matter volume in the left inferior frontal gyrus and the severity of AVHs.
  • Demonstrated that hallucination severity significantly influenced structural covariance patterns between the left inferior frontal gyrus and other brain regions, including the temporal gyri, right inferior frontal gyrus, hippocampus, and insula.

Conclusions:

  • The severity of AVHs modulates cortical intercorrelations within frontotemporal networks crucial for language processing and verbal monitoring.
  • These findings support the involvement of this frontotemporal network in the pathophysiology of auditory verbal hallucinations in schizophrenia.