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Published on: December 10, 2016
Evaluation of ceftriaxone utilization at multicenter study.
Hyuck Lee1, Dongsik Jung, Joon Sup Yeom
1Department of Internal Medicine, Dong-A University Hospital, Busan, Korea.
The Korean Journal of Internal Medicine
|December 2, 2009
Summary
Ceftriaxone use was appropriate in 65.5% of cases at Korean hospitals, but inappropriate use, including continued empiric therapy, remains high. Educational programs and antibiotic control systems are needed to improve antimicrobial stewardship.
Area of Science:
- Infectious Diseases
- Pharmacology
- Hospital Pharmacy
Background:
- Rising bacterial resistance to antimicrobials necessitates evaluation of current drug usage.
- Ceftriaxone, a third-generation cephalosporin, is widely used in hospital settings.
- Assessing ceftriaxone utilization is crucial for antimicrobial stewardship.
Purpose of the Study:
- To evaluate the appropriateness of ceftriaxone usage in Korean university hospitals.
- To identify common reasons for inappropriate ceftriaxone prescribing.
- To inform strategies for improving antimicrobial use.
Main Methods:
- Prospective drug utilization evaluation (DUE) of 400 adult patients receiving ceftriaxone.
- Utilized modified DUE criteria based on American Society of Hospital Pharmacists standards.
- Assessed justification of drug use, indications, complications, and outcomes.
Main Results:
- Appropriate ceftriaxone use was observed in 65.5% of cases; inappropriate use in 34.5%.
- Common inappropriate uses included continued empiric therapy and prophylactic perioperative injection.
- Clinical response rates were 60.7%, with only 15.7% achieving culture-proven infection eradication.
Conclusions:
- While appropriate ceftriaxone use exceeded inappropriate use, significant areas for improvement exist.
- Continued empiric use and prophylactic administration highlight the need for better antibiotic control.
- Enhanced educational programs and antibiotic stewardship systems are recommended to optimize ceftriaxone utilization.
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