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Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
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C1 domain mediates CalDAGIII localization to the Golgi

Mingyu Zhang1, Hongyuan Xia, Xueqi Li

  • 1Department of Cardiology, The 4th Affiliated Hospital of Harbin Medical University, 150001, Harbin, Peoples Republic of China.

Molecular Biology Reports
|December 2, 2009
PubMed
Summary

Calcium and DAG diacylglycerol (DAG) signaling proteins, known as CalDAGs, are crucial for cell function. This study reveals that the C1 domain, not calcium-binding EF hands, dictates CalDAGIII localization and activity in B cells, suggesting DAG regulation.

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