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Updated: Jun 18, 2026
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Bioactive diterpenes from the aerial parts of Anisochilus harmandii
Ratsami Lekphrom1, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul
1Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
Abstract:
Two new diterpenes, 4- EPI-triptobenzene L ( 1) and 12- O-deacetyl-6- O-acetyl-19- acetyloxycoleon Q ( 2), as well as eight known diterpenes ( 3- 10) were isolated from the aerial parts of Anisochilus hamandii. Structures of the isolated compounds were identified from spectroscopic evidence. Compounds 1, 2, 5, and 10 exhibited antiplasmodial activity against Plasmodium falciparum (IC (50) 4.70, 2.90, 3.03, and 7.20 microg/mL, respectively), while 3, 5, and 7 showed antimycobacterial activity against Mycobacterium tuberculosis (MIC 50 microg/mL). In addition, only 10 showed strong cytotoxicity against NCI-H187 cells (IC (50) 4.43 microg/mL).
