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Updated: Jun 18, 2026

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses
Published on: July 7, 2017
[Association between interleukin-8 in lung tissues and stages of chronic obstructive pulmonary diseases]
Xiao-Rong Hu1, Su-Xia Han, Tao Wang
1Department of Respiratory Medicine, Division of Pulmonary Diseases, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Objective:
To investigate the expression of interleukin (IL)-8 in lung tissues from patients with chronic obstructive pulmonary disease (COPD) and its association with stages of COPD.
Methods:
The levels of mRNA and protein of IL-8 were measured with semi-quantitative polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) in patients with mild COPD (n=21), patients with advanced COPD (n=15), and controls (n=15). The correlations between IL-8 levels and stages of COPD, lung function (FEV1/ FVC%, FEV1% pred) and cigarette smoking were analyzed with Pearson correlation analysis.
Results:
The levels of IL-8 mRNA and protein in the lung tissues of COPD patients were significantly higher than those in the control group (P<0.05). The patients with advanced COPD had higher levels of IL-8 mRNA and protein than the patients with mild COPD (P<0.05). The COPD patients who smoked had higher levels of IL-8 mRNA and protein than those who did not smoke (P<0.05). But no significant differences in the levels of IL-8 mRNA and protein were found between smokers and and nonsmokers who did not have COPD (P>0.05). Increased expression of IL-8 in patients with COPD was positively correlated with stages of COPD (r=0.81, P<0.05); negatively correlated with lung function (FEV1/FVC%, FEV1% pred) (r=-0.62, -0.56, P<0.05), and positively correlated with volumes of cigarette smoking (r=0.53, P<0.05).
Conclusion:
IL-8 is associated with stages of COPD, which may serve as an indication for clinical progress. Cigarette smoking increases IL-8 expression in the lung tissues of COPD patients.
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