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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Documentation in Long-Term and Home Healthcare Setting01:29

Documentation in Long-Term and Home Healthcare Setting

Documentation in long-term care facilities and home healthcare settings is crucial for ensuring continuous, coordinated, and comprehensive care for patients. Each setting has its specific documentation processes and tools:
Long-Term Care Facilities
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...

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Related Experiment Video

Updated: Jun 18, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Methicillin-resistant Staphylococcus aureus in long-term-care facilities.

A Manzur1, F Gudiol

  • 1IDIBELL, Infectious Diseases Service, Hospital de Bellvitge, University of Barcelona, Barcelona, Spain.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|December 3, 2009
PubMed
Summary

Long-term-care facilities (LTCFs) are reservoirs for methicillin-resistant Staphylococcus aureus (MRSA). While colonization is common and persistent, MRSA infections are infrequent in LTCFs, but pose risks in acute care settings.

Related Experiment Videos

Last Updated: Jun 18, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Healthcare-Associated Infections

Background:

  • Long-term-care facilities (LTCFs) harbor a high prevalence of methicillin-resistant Staphylococcus aureus (MRSA), acting as significant reservoirs.
  • Limited data exist on the natural history and long-term dynamics of MRSA colonization within LTCF populations.

Purpose of the Study:

  • To describe the epidemiology of MRSA colonization in LTCFs.
  • To identify risk factors associated with MRSA colonization.
  • To evaluate the clinical and epidemiological impact of MRSA colonization in LTCFs.

Main Methods:

  • Review of existing literature and clinical data on MRSA prevalence and colonization in LTCFs.
  • Analysis of host-related factors contributing to colonization risk.
  • Assessment of infection outcomes and transmission potential in different healthcare settings.

Main Results:

  • The cumulative incidence of MRSA colonization in LTCFs is approximately 20% annually, with over half of carriers experiencing persistent colonization.
  • Risk factors for colonization include antibiotic use, presence of invasive devices, and suboptimal infection control practices.
  • MRSA-infected residents in LTCFs rarely develop severe infections, but colonized individuals pose a transmission risk in acute-care settings.

Conclusions:

  • The epidemiological impact of MRSA in LTCFs, particularly concerning transmission in acute care, outweighs the individual clinical impact within the LTCF.
  • Routine application of standard precautions is recommended for all LTCF residents.
  • Targeted interventions like barrier precautions and decolonization should be reserved for managing MRSA outbreaks.