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Dyslipidaemia among diabetic patients with ischemic stroke in a Chinese hospital

Shao-hua Wang1, Zi-lin Sun, Xiong-zhong Ruan

  • 1Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu 210009, China.

Chinese Medical Journal
|December 3, 2009
PubMed

Insights

Diabetic patients with ischemic stroke often have uncontrolled dyslipidemia, with lower adherence to lipid-lowering therapy. Achieving intensified low-density lipoprotein-cholesterol (LDL-C) goals may help prevent stroke in this population.

Area of Science:

  • Cardiology
  • Neurology
  • Endocrinology

Background:

  • Dyslipidemia is a significant risk factor for cerebrovascular disease in diabetic patients.
  • Investigating dyslipidemia prevalence, treatment, and control in Chinese diabetic patients with ischemic stroke is crucial.

Purpose of the Study:

  • To analyze dyslipidemia characteristics, treatment adherence, and control status among type 2 diabetic patients with ischemic stroke.
  • To compare these metrics between diabetic patients with and without stroke.

Main Methods:

  • A cohort of 1046 type 2 diabetic patients were divided into stroke and non-stroke groups, matched for key demographics.
  • Lipid and lipoprotein profiles were measured, and control was assessed against ADA guidelines and Chinese criteria.
  • Adherence to prescribed dyslipidemia therapy was evaluated.

Main Results:

  • Diabetic patients with stroke showed poorer lipid profiles, including lower achievement of intensified LDL-C and HDL-C targets.
  • Adherence to dyslipidemia therapy was significantly lower in the stroke group (30.8% vs. 41.0%).
  • Diabetic women with stroke exhibited worse dyslipidemia, with lower HDL-C and apoA1, and higher LDL-C and apoB/apoA1 ratio.

Conclusions:

  • A substantial proportion of diabetic patients with ischemic stroke have uncontrolled dyslipidemia.
  • Intensified LDL-C targets and comprehensive lipid-lowering strategies are vital for stroke prevention in Chinese diabetic patients.
Abstract

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