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The cytochrome p450 homepage.

David R Nelson1

  • 1Department of Molecular Sciences, University of Tennessee, 858 Madison Avenue, Memphis, TN 38163, USA. dnelson@uthsc.edu

Human Genomics
|December 3, 2009
PubMed
Summary

The Cytochrome P450 Homepage offers comprehensive nomenclature and sequence data for over 11,512 cytochrome P450 (CYP) genes. This manually curated resource follows an evolutionary scheme for consistent CYP gene classification.

Area of Science:

  • Biochemistry
  • Genomics
  • Bioinformatics

Background:

  • Cytochrome P450 (CYP) enzymes are crucial in drug metabolism and biosynthesis.
  • A standardized nomenclature system is essential for understanding CYP gene evolution and function.
  • The Cytochrome P450 Homepage has served as a central repository since 1995.

Purpose of the Study:

  • To describe the organization and content of the Cytochrome P450 Homepage.
  • To highlight its role as a universal resource for CYP nomenclature and sequence information.
  • To emphasize the evolutionary basis of the CYP naming system.

Main Methods:

  • Manual curation of P450 sequences by David Nelson.
  • Implementation of an evolutionary scheme for CYP family and subfamily classification.

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  • Web-based accessibility of nomenclature and sequence data.

    • Main Results:

    • The Homepage provides naming information for 11,512 CYP genes.
    • The nomenclature system reflects the evolutionary relationships among CYP genes.
    • The resource has been continuously operational since February 1995.

    Conclusions:

    • The Cytochrome P450 Homepage is a vital, long-standing resource for the scientific community.
    • Its evolutionary nomenclature facilitates accurate CYP gene identification and comparison.
    • The manually curated data ensures the reliability of CYP information.