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Updated: Jun 18, 2026

Frailty Assessment in an Aging Mouse Model
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Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

Longevity in mice without a father.

Manabu Kawahara1, Tomohiro Kono

  • 1Laboratory of Animal Resource Development, Faculty of Agriculture, Saga University, 1 Honjo-machi, Saga 840-8502, Japan.

Human Reproduction (Oxford, England)
|December 3, 2009
PubMed
Summary

Bi-maternal mice, created without male DNA, lived significantly longer than control mice. This suggests the paternal genome may negatively impact mammalian longevity.

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Area of Science:

  • Genetics
  • Mammalian Longevity
  • Reproductive Biology

Background:

  • Females generally exhibit longer lifespans than males across many mammalian species.
  • The underlying biological mechanisms driving this sex difference in longevity remain largely unelucidated.
  • Bi-maternal mice offer a unique model to study longevity without paternal genetic influence.

Purpose of the Study:

  • To investigate the role of the maternal genome in determining longevity.
  • To analyze the lifespan of bi-maternal mice lacking paternal genomes.
  • To explore potential genomic origins of sex differences in lifespan.

Main Methods:

  • Bi-maternal mice were generated using two sets of female genomes, with genetic manipulation of imprinting centers.
  • Lifespan was determined by comparing bi-maternal mice to control groups.
  • Body weight and leukocyte composition were analyzed at specific time points.

Main Results:

  • Bi-maternal mice exhibited a significant increase in lifespan, surviving 186 days longer than controls.
  • A rightward shift in the survival curve indicated a delay in mortality causes for bi-maternal mice.
  • Bi-maternal mice showed lower body weight and increased eosinophil counts compared to controls.

Conclusions:

  • The maternal genome appears to play a crucial role in ontogenetic longevity.
  • Genomic imprinting may contribute to sex differences in lifespan.
  • The paternal genome may exert a detrimental effect on longevity in mammals.

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