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Related Experiment Video

Updated: Jun 18, 2026

Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices

Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices

Published on: June 13, 2025

Liquid versus foam sclerotherapy.

C Hamel-Desnos¹, F-A Allaert

¹Department of Vascular Medicine, Saint Martin Private Hospital, 18 rue des Roquemonts, 14050 Caen, France. claudine@desnos.eu

|December 3, 2009

Summary

This summary is machine-generated.

Foam sclerotherapy is significantly more effective than liquid sclerotherapy for treating varicose veins. Both methods show similar safety profiles, with no statistically significant differences in side effects.

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Area of Science:

Vascular Surgery
Dermatology
Medical Interventions

Background:

Varicose veins are a common condition affecting the lower limbs.
Sclerotherapy is a standard treatment for varicose veins.
Foam sclerotherapy (F) and liquid sclerotherapy (L) are two common methods.

Purpose of the Study:

To systematically review and compare the efficacy and safety of foam sclerotherapy versus liquid sclerotherapy.
To evaluate treatment outcomes for primary varicose veins of the lower limbs.

Main Methods:

Systematic literature searches of electronic databases were conducted in April 2009.
Searches were augmented by conference abstracts and hand-searching of journals.
Six trials, including four randomized controlled trials, were included for saphenous vein treatment.

Main Results:

Foam sclerotherapy demonstrated markedly higher efficacy (76.8%) compared to liquid sclerotherapy (39.5%) for saphenous veins.
The difference in efficacy ranged between 20% and 50%.
No statistically significant differences in side effects were found between foam and liquid sclerotherapy, although visual disturbances were more frequent with foam.

Conclusions:

Foam sclerotherapy is significantly more effective than liquid sclerotherapy for treating varicose veins in the lower limbs.
The safety profiles of both foam and liquid sclerotherapy are comparable.
Further research is needed for reticular veins and telangiectases.