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Related Concept Videos

In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
Drug Dissolution: Requirements and Profile Comparison01:14

Drug Dissolution: Requirements and Profile Comparison

The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...
Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...

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Related Experiment Video

Updated: Jun 18, 2026

Dissolved Solute Sampling Across an Oxic-Anoxic Soil-Water Interface Using Microdialysis Profilers
11:43

Dissolved Solute Sampling Across an Oxic-Anoxic Soil-Water Interface Using Microdialysis Profilers

Published on: March 24, 2023

[Improvement of dissolution test using microdialysis method].

Noriaki Nagai1, Takatoshi Murao, Yoshimasa Ito

  • 1School of Pharmacy, Kinki University, Higashi-Osaka, Japan.

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|December 3, 2009
PubMed
Summary

Microdialysis offers an improved dissolution testing method for pharmaceuticals, showing similar results to HPLC but with lower variability. This technique streamlines drug development and quality control for both novel and generic products.

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Custom-made Microdialysis Probe Design
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Custom-made Microdialysis Probe Design

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Microdialysis of Ethanol During Operant Ethanol Self-administration and Ethanol Determination by Gas Chromatography
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Microdialysis of Ethanol During Operant Ethanol Self-administration and Ethanol Determination by Gas Chromatography

Published on: September 5, 2012

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Last Updated: Jun 18, 2026

Dissolved Solute Sampling Across an Oxic-Anoxic Soil-Water Interface Using Microdialysis Profilers
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Dissolved Solute Sampling Across an Oxic-Anoxic Soil-Water Interface Using Microdialysis Profilers

Published on: March 24, 2023

Custom-made Microdialysis Probe Design
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Custom-made Microdialysis Probe Design

Published on: July 21, 2015

Microdialysis of Ethanol During Operant Ethanol Self-administration and Ethanol Determination by Gas Chromatography
10:11

Microdialysis of Ethanol During Operant Ethanol Self-administration and Ethanol Determination by Gas Chromatography

Published on: September 5, 2012

Area of Science:

  • Pharmaceutical Sciences
  • Analytical Chemistry
  • Drug Delivery

Context:

  • Dissolution testing is crucial for pharmaceutical development and quality control.
  • High-performance liquid chromatography (HPLC) is the conventional method for analyzing dissolution tests.
  • Existing methods involve multiple steps like filtration and sample replenishment.

Purpose:

  • To evaluate microdialysis as an improved method for dissolution testing.
  • To compare the microdialysis dissolution test with the conventional HPLC batch-sampling method.
  • To assess the dissolution behavior of cimetidine tablets using both methods.

Summary:

  • Microdialysis dissolution testing demonstrated similar results to the conventional HPLC batch-sampling method for cimetidine tablets.
  • The microdialysis method exhibited a lower standard deviation, indicating improved precision.
  • Microdialysis simplifies the process by omitting filtration, collection, and replenishment steps, enabling continuous sampling.

Impact:

  • Microdialysis provides a more efficient and precise dissolution testing method.
  • This technique offers significant advantages for pharmaceutical development and quality control.
  • The findings are applicable to both original and generic pharmaceutical product assessment.