Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Oral Drug Delivery Systems: Introduction

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.

Micelles

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...

Oral Drug Delivery Systems: Delayed-Release Systems

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

Bioavailability Enhancement: Drug Permeability Enhancement

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...

Oral Drug Delivery Systems: Continuous-Release Systems

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Redox-Active NiO<sub>x</sub>-Catalyzed Li<sup>+</sup> Capture-Extraction Strategy for tBP-Free Spiro-OMeTAD Enables Exceptional Damp-Heat Stability in Perovskite Solar Cells.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Ready-to-use, drug nanocrystals-forming hydrogel system with hyaluronic acid for subcutaneous prolonged delivery of donepezil.

International journal of biological macromolecules·2026

Same author

Sustained-Release Intra-Articular Drug Delivery: PLGA Systems in Clinical Context and Evolving Strategies.

Pharmaceutics·2025

Same author

Design of Electrostatic Nanocomplex of Semaglutide with Protamine and Zinc for Subcutaneous Prolonged Delivery.

Nanomaterials (Basel, Switzerland)·2025

Same author

Intrinsic and Extrinsic Determinants of Stability in Spiro-OMeTAD-Based Hole-Transporting Layers in Perovskite Solar Cells: Mechanistic Insights and Strategic Perspectives.

Advanced materials (Deerfield Beach, Fla.)·2025

Same author

Single junction CsPbBr<sub>3</sub> solar cell coupled with electrolyzer for solar water splitting.

Nature communications·2025

Search research articles

Related Experiment Video

Updated: Jun 18, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Self-microemulsifying formulation-based oral solution of coenzyme Q10.

Dong Woo Seo¹, Myung Joo Kang, Yesung Sohn

¹College of Pharmacy, Chung-Ang University, Seoul, Korea.

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan

|December 3, 2009

Summary

Researchers developed a stable oral coenzyme Q10 (CoQ10) solution using self-emulsifying systems. This overcomes CoQ10

More Related Videos

Single Liposome Measurements for the Study of Proton-Pumping Membrane Enzymes Using Electrochemistry and Fluorescent Microscopy

Single Liposome Measurements for the Study of Proton-Pumping Membrane Enzymes Using Electrochemistry and Fluorescent Microscopy

Published on: February 21, 2019

Related Experiment Videos

Last Updated: Jun 18, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Single Liposome Measurements for the Study of Proton-Pumping Membrane Enzymes Using Electrochemistry and Fluorescent Microscopy

Single Liposome Measurements for the Study of Proton-Pumping Membrane Enzymes Using Electrochemistry and Fluorescent Microscopy

Published on: February 21, 2019

Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems
Formulation Development

Background:

Coenzyme Q10 (CoQ10) exhibits poor water solubility, hindering oral solution development.
Effective oral delivery of CoQ10 is crucial for its therapeutic applications.

Purpose of the Study:

To develop a stable oral solution of CoQ10 using self-emulsifying systems.
To enhance the bioavailability of CoQ10 through improved oral formulation.

Main Methods:

Investigated various oil, surfactant, and co-surfactant combinations for self-emulsifying systems.
Selected acetylated monoglyceride (AM), polyoxyethylene (20) sorbitan monolaurate (P2SM), and propylene glycol laurate (PGL) based on emulsification properties.
Formulated CoQ10 oral solutions using the optimized self-emulsifying system.

Main Results:

A self-emulsifying system comprising AM (10%), P2SM (70%), and PGL (20%) demonstrated spontaneous emulsification and transparency.
Successfully developed stable CoQ10 oral solutions at concentrations of 100 mg/70 ml and 100 mg/100 ml.
The final oral solution formulation remained stable for over one month.

Conclusions:

Self-emulsifying systems offer an effective approach for formulating poorly soluble CoQ10 into stable oral solutions.
The developed CoQ10 oral solution is suitable for potential use in functional foods.
This formulation strategy significantly improves oral delivery of CoQ10.