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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
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The risk of psychopathology in children with craniosynostosis

Joris J B van der Vlugt1, Jacques J N M van der Meulen, Hanneke E Creemers

  • 1Rotterdam, The Netherlands From the Departments of Plastic and Reconstructive Surgery, Child and Adolescent Psychiatry, and Radiology and the Netherlands Institute of Health Sciences, Erasmus Medical Center.

Plastic and Reconstructive Surgery
|December 3, 2009
PubMed

Insights

Craniosynostosis does not increase behavioral issues when intelligence is considered. A specific skull pattern (beaten-copper) before 18 months also showed no link to emotional problems in these patients.

Area of Science:

  • Pediatric Neurology
  • Developmental Psychology
  • Medical Genetics

Background:

  • Craniosynostosis, a condition of premature skull fusion, may impact neurodevelopment.
  • Behavioral and emotional problems are concerns in children with craniosynostosis.

Purpose of the Study:

  • To determine the prevalence of behavioral and emotional problems in craniosynostosis patients.
  • To investigate the association between a beaten-copper skull pattern and behavioral issues.

Main Methods:

  • Follow-up study of 115 craniosynostosis patients.
  • Behavioral problems assessed using the Child Behavior Checklist at age 8.
  • Beaten-copper pattern evaluated on presurgical radiographs; analyses adjusted for IQ.

Main Results:

  • Patients with IQ < 85 had higher risk of behavioral problems, consistent with general population findings.
  • No significant association found between craniosynostosis type (single vs. complex) and behavioral problems.
  • A beaten-copper pattern before 18 months did not influence the risk of behavioral or emotional problems.

Conclusions:

  • Craniosynostosis itself is not linked to increased behavioral or emotional problems when intelligence is accounted for.
  • Skull morphology, including the beaten-copper pattern, and craniosynostosis type do not predict behavioral outcomes.
  • Intelligence quotient is a key factor in understanding psychopathology in craniosynostosis patients.
Abstract

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