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Intracranial volumes in a large series of healthy children

Mehul R Kamdar1, R Alex Gomez, Jeffrey A Ascherman

  • 1New York, N.Y. From the Division of Plastic Surgery, Department of Surgery, New York Presbyterian Hospital, Columbia University College of Physicians and Surgeons, and Weill Cornell Medical College.

Plastic and Reconstructive Surgery
|December 3, 2009
PubMed

Insights

Intracranial volume in healthy children doubles by 9 months and triples by 6 years. These findings provide crucial reference data for assessing pediatric cranial conditions.

Area of Science:

  • Pediatric neurosurgery
  • Craniofacial development
  • Medical imaging analysis

Background:

  • Craniosynostosis significantly impacts infant skull growth, potentially affecting intracranial pressure and volume.
  • Establishing normative intracranial volume data is essential for understanding craniosynostosis and surgical interventions.

Purpose of the Study:

  • To establish normative intracranial volume measurements in a large cohort of healthy children.
  • To provide a reference dataset for evaluating conditions like craniosynostosis and the effects of vault remodeling.

Main Methods:

  • Retrospective analysis of 123 children undergoing head CT scans for trauma evaluation.
  • Semiautomated image segmentation and volume-rendering software used for intracranial volume quantification.

Main Results:

  • Intracranial volume measurements were plotted against age, and a best-fit curve was generated.
  • In healthy children, intracranial volume doubles by 9 months and triples by 6 years of age.

Conclusions:

  • This study presents a comprehensive dataset of intracranial volumes in healthy children up to age 6.
  • The derived data serve as a valuable clinical reference for assessing pediatric cranial abnormalities and developmental variations.
Abstract

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