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Updated: Jun 18, 2026
05:21
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Published on: September 12, 2025
Angioleiomyomas in the bilateral broad ligaments
Xiaoduan Chen1, Xiaofei Zhang, Suojiang Zhang
1Department of Pathology, The Affiliated Women's Hospital, School of Medicine, Zhejiang University, Zhejiang Province, PR China.
Summary
This case report details a rare occurrence of bilateral angioleiomyoma in the broad ligaments of a 52-year-old woman. These benign tumors highlight the importance of differentiating them from other mesenchymal neoplasms.
Area of Science:
- Gynecologic Pathology
- Vascular Tumors
- Female Reproductive System Neoplasms
Background:
- Angioleiomyomas are rare benign tumors typically found in the extremities.
- The female genital tract is an exceptionally uncommon location for angioleiomyomas.
Observation:
- A 52-year-old woman presented with massive bilateral adnexal tumors requiring hysterectomy and bilateral salpingo-oophorectomy.
- Gross examination revealed large, hemangioma-like masses in both broad ligaments, with extension into the myometrium on the right.
- Histological analysis showed a mixed pattern of thick-walled blood vessels and spindle myoid cells, resembling angiomyofibroblastoma or myopericytoma.
Findings:
- Immunohistochemical staining confirmed tumor cells were positive for alpha-smooth muscle actin, desmin, estrogen receptor, and progesterone receptor.
- The histological features and immunohistochemical profile support the diagnosis of angioleiomyoma.
Implications:
- This case suggests angioleiomyoma should be recognized as a distinct variant of leiomyoma within the female genital tract.
- Accurate differentiation from other vascular mesenchymal neoplasms is crucial for appropriate clinical management.
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