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Related Concept Videos

Fatigue01:21

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

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Updated: Jun 18, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

[Fatigue and anemia].

K Ivanova1, A Zeller

  • 1Medizinische Poliklinik, Universitätsspital Basel. IvanovaK@uhbs.ch

Praxis
|December 3, 2009
PubMed
Summary
This summary is machine-generated.

An 80-year-old male with fatigue and weight loss was diagnosed with secondary chronic adrenal insufficiency and anemia of chronic disease. Treatment with hydrocortisone fully resolved his symptoms, demonstrating effective management of these interconnected conditions.

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The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
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Area of Science:

  • Endocrinology
  • Hematology
  • Internal Medicine

Context:

  • Presents an 80-year-old male experiencing prolonged muscle weakness, fatigue, and weight loss.
  • Highlights diagnostic challenges in elderly patients with nonspecific symptoms.

Purpose:

  • To report a case of secondary chronic adrenal insufficiency and anemia of chronic disease.
  • To illustrate the diagnostic process and successful treatment outcomes.

Summary:

  • A pathologic synacthen test and low ACTH levels indicated secondary chronic adrenal insufficiency.
  • Bone marrow biopsy revealed anemia of chronic disease, characterized by normochromic, normocytic, and hypoproliferative anemia.
  • Initiation of hydrocortisone therapy led to complete resolution of the patient's anemia and overall symptoms.

Impact:

  • Demonstrates the successful management of secondary chronic adrenal insufficiency and anemia of chronic disease with hydrocortisone.
  • Underscores the importance of considering endocrine and hematologic evaluations in elderly patients with constitutional symptoms.
  • Provides a clinical case for understanding the interplay between adrenal insufficiency and anemia.