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Updated: Jun 18, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
[Expression and significance of CD147 protein in prostate cancer]
Hui-Chan He1, Zhao-Dong Han, Qi-Shan Dai
1Department of Urology, First Municipal People's Hospital Affiliated to Guangzhou Medical College, Guangzhou 510182, China.
Objective:
To investigate the expression of CD147 in prostate cancer and discuss its diagnostic value in prostate cancer.
Methods:
The method of immunohistochemical SP was employed to detect the expression of CD147 in 101 cases of prostate cancer, 90 cases of benign prostatic hyperplasia, 36 cases of normal prostate and 15 cases of embryonic prostate by so as to evaluate its clinical significance in the histological classification and prognosis of prostate cancer.
Results:
The CD147 expression was positively expressed in 67/101 (66.3%) of prostate cancer, 21/90 (23.3%) of benign prostatic hypertrophy, 2/36 (5.6%) of normal prostate and 0/15 (0.0) of embryonic prostate respectively. A positive expression of CD147 was dramatically associated with TNM stage (P < 0.001), the depth of prostatic capsule invasion (P = 0.002) and histological grade (P = 0.006).
Conclusions:
The detection of CD147 is helpful to raise the early diagnosis rate of prostate cancer. It will become a tumor marker of reflecting the malignant degree and predicting the prognosis of prostate cancer.
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