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Updated: Jun 18, 2026

Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
[Periapical surgery with histologic examination of the periapical lesion. A case report]
Malte Schulz1, Dieter Bosshardt, Thomas von Arx
1Klinik für Oralchirurgie und Stomatologie, Zahnmedizinische Kliniken der Universität Bern.
Abstract:
Periapical surgery is required when periradicular pathosis associated with endodontically treated teeth cannot be resolved by nonsurgical root canal therapy (retreatment), or when retreatment was unsuccessful, not feasible or contraindicated. Endodontic failures can occur when irritants remain within the confines of the root canal, or when an extraradicular infection cannot be eradicated by orthograde root canal treatment. Foreign-body reponses towards filling materials, towards cholesterol crystals or radicular cysts might prevent complete periapical healing. Following enhanced microsurgical techniques in the last years the success rates of apical surgery have improved considerably. The aim of the current case report is to describe the therapeutical approach to a persistent periapical lesion and its histologic examination.