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Updated: Jun 18, 2026

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Solid-phase synthesis of thiazolo[4,5-b]pyridine derivatives using Friedländer reaction
Taeho Lee1, Doohyun Lee, Ill Young Lee
1Center for High Throughput Synthesis Platform Technology, Korea Research Institute of Chemical Technology, Yuseong-gu, Daejeon, Korea. taeholee@krict.re.kr
Abstract:
Traceless solid-phase synthesis of 2,5,6,7-tetrasubstituted thiazolo[4,5-b]pyridine derivatives is described. Thorpe-Ziegler type cyclization of solid supported cyanocarbonimidodithioate with alpha-halo ketones afforded thiazole resin, which were converted to the desired thiazolopyridine resin by the Friedländer protocol under microwave irradiation conditions. After oxidation of sulfides to sulfones, nucleophilic desulfonative substitution with amines gave the target thiazolo[4,5-b]pyridine derivatives in good overall yields.
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