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Updated: Jun 18, 2026

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Diversity oriented synthesis of benzoxanthene and benzochromene libraries via one-pot, three-component reactions and
Atul Kumar1, Siddharth Sharma, Ram Awatar Maurya
1Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow, India. dratulsax@gmail.com
Abstract:
Libraries of benzoxanthenes, as well as of benzochromenes, were efficiently synthesized via one-pot, three-component reactions of 2-naphthol, aldehydes, and cyclic 1,3-diketones/malononitrile/ethyl cyanoacetate in the presence of catalytic amount of ceric ammonium nitrate (CAN) under solvent free conditions. The protocol offers rapid synthesis of structurally diverse benzoxanthenes and benzochromenes for biologically screening. All the synthesized compounds were evaluated for their anti-proliferative activity, and several compounds were exhibiting promising anti-proliferative activity.
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