Related Experiment Video
Updated: Jun 18, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
A physician-friendly alternative to prior authorization for prescription drugs
Steven E Wegner1, Troy K Trygstad, L Allen Dobson
1AccessCare, 3500 Gateway Centre Blvd, Ste 130, Morrisville, NC 27560, USA. sew@ ncaccesscare.org
Objective:
To determine if the instant approval (IA) process differs from the traditional prior authorization (PA) process in preferred drug channeling, resultant gaps in therapy, and provider dissatisfaction.
Study Design:
An interrupted time series analysis using pharmacy claims and a retrospective cohort study.
Methods:
The study assessed changes in preferred drug use and subsequent cost reductions. A retrospective cohort study determined if the IA process produced fewer gaps in therapy than the PA process. Provider acceptance of the IA process was assessed using a brief survey of 240 randomly selected primary care practices.
Results:
Market share for preferred proton pump inhibitors quadrupled from a range of 17.6% to 19.3% at baseline to 76% in the first month after implementation of the new IA policy. Most practices (81.1%) reported reduced administrative burden with the IA process. The median gaps between medication fills for patients using IA were approximately one-half those of patients using PA (P <.001) and were one-fourth in a subset of highly adherent, regularly filling patients (P <.001).
Conclusions:
Instant approval may be more patient friendly and prescriber friendly than PA as assessed by a proxy measure for access (gap in therapy) and physician-reported acceptance. Despite its ease of use, IA does not seem to reduce switching to preferred drugs.
Related Concept Videos
Prescription, Nonprescription and Orphan Drugs
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Drug Nomenclature
Prodrugs
Prodrugs help overcome...
Drug Classes and Categories
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
FDA Approved Drugs: Changes to Approved Drugs

