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Hyperhomocysteinemia in patients with stasis dermatitis and ulcer: a novel finding with important therapeutic

Selda Pelin Kartal Durmazlar1, Ahmet Akgul, Fatma Eskioglu

  • 1Department of Dermatology, Ministry of Health Ankara Diskapi Yildirimi Beyazit Education and Research Hospital, Ankara, Turkey. pelin@dr.com

The Journal of Dermatological Treatment
|December 4, 2009
PubMed

Insights

Elevated homocysteine (Hcy) levels are significantly present in patients with stasis dermatitis and stasis ulcer. Lowering Hcy through vitamin supplementation may prevent ulcer formation in stasis dermatitis.

Area of Science:

  • Vascular Biology
  • Dermatology
  • Metabolic Disorders

Background:

  • Homocysteine (Hcy) is implicated in vascular lesions and thrombosis.
  • Its role in stasis dermatitis and ulceration has not been previously explored.

Purpose of the Study:

  • To investigate plasma homocysteine (Hcy) levels in patients diagnosed with stasis dermatitis and stasis ulcer.
  • To compare Hcy levels between these patient groups and healthy controls.

Main Methods:

  • Plasma Hcy levels were measured in 25 patients with stasis dermatitis, 40 with stasis ulcer, and 35 healthy controls.
  • Exclusion criteria included vitamin supplement use, deficiencies (folic acid, B12), diabetes, chronic hepatitis, renal failure, and alcoholism.

Main Results:

  • Patients with stasis dermatitis and stasis ulcer exhibited significantly elevated Hcy levels compared to healthy controls (p=0.00).
  • Median Hcy levels were 19.1 micromol/l for stasis dermatitis, 18.98 micromol/l for stasis ulcer, and 8.1 micromol/l for controls.
  • No significant difference in Hcy levels was observed between stasis dermatitis and stasis ulcer patients (p=0.877).

Conclusions:

  • Hyperhomocysteinemia is a notable finding in stasis dermatitis and stasis ulcer.
  • Vitamin supplementation offers a potential therapeutic strategy to lower Hcy and prevent ulcer formation in the early stages of stasis dermatitis.
Abstract

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