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Updated: Jun 18, 2026
Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
[Compound huangdai tablet as induction therapy for 193 patients with acute promyelocytic leukemia]
Yang Xiang1, Xiao-Bo Wang, Shu-Jun Sun
1Department of Traditional Chinese Medicine & Hematology, 210th Hospital of PLA, Dalian 116021, China.
Objective:
To report the results of curative and adverse effects of compound huangdai tablet (CHDT) as induction therapy for 193 patients with acute promyelocytic leukemia (APL).
Methods:
CHDT was administered 1.25 g orally three times a day after meal for three days, then the dosage was gradually increased to 7.5 g/d.
Results:
One hundred and ninety-three patients achieved complete remission (CR), 78.8% of whom in 30 to 60 days with an average time of 44.3 d. No serious infection, bleeding or DIC occurred during the treatment course. The major adverse effects were gastrointestinal symptoms. There was no change in lanine transaminase, urea, creatinine or electrocardiographic QTc interval in 110 APL patients observed before and after the treatment.
Conclusion:
CHDT therapy is a modality of higher CR rate, good safety and tolerance without bone marrow suppression for APL patients.
