Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multiple Sclerosis l: Introduction

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

Myasthenia Gravis: Diagnostic Tests

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

Myasthenia Gravis ll: Pathophysiology

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ugeskrift for laeger·2023

Same author

The effect of lacosamide in peripheral neuropathic pain: A randomized, double-blind, placebo-controlled, phenotype-stratified trial.

European journal of pain (London, England)·2023

Same author

Oral capsules of tetra-hydro-cannabinol (THC), cannabidiol (CBD) and their combination in peripheral neuropathic pain treatment.

European journal of pain (London, England)·2022

Same author

Comparison of diabetic and idiopathic sensory polyneuropathies with respect to nerve fibre affection and risk factors.

BMJ neurology open·2022

Same author

Investigating the potential disease-modifying and neuroprotective efficacy of exercise therapy early in the disease course of multiple sclerosis: The Early Multiple Sclerosis Exercise Study (EMSES).

Multiple sclerosis (Houndmills, Basingstoke, England)·2022

Same author

[Chronic inflammatory demyelinating polyneuropathy].

Ugeskrift for laeger·2019

Search research articles

Related Experiment Video

Updated: Jun 18, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

[Neuromyelitis optica--an important differential diagnosis for multiple sclerosis].

Jakob Vormstrup Holbech¹, Masoud Falah

¹Neurologisk Afdeling N, Odense Universitetshospital, DK-5000 Odense C, Denmark. Holbech@dadlnet.dk

Ugeskrift for Laeger

|December 4, 2009

Summary

Neuromyelitis optica (Devic's disease) is a rare autoimmune disorder. Early diagnosis and familiarity are crucial due to its potential for rapid disability progression.

More Related Videos

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice

Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice

Published on: March 1, 2017

Related Experiment Videos

Last Updated: Jun 18, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice

Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice

Published on: March 1, 2017

Area of Science:

Neuroimmunology
Autoimmune diseases
Neurology

Background:

Neuromyelitis optica (Devic's disease) is a rare autoimmune neuroinflammatory condition.
Distinguishing Devic's disease from multiple sclerosis can be challenging.
Prompt recognition is vital due to the risk of severe disability or mortality.

Observation:

A case study of a 15-year-old female patient is presented.
The patient exhibited a typical relapsing-remitting disease course.
The case details diagnostic procedures and therapeutic interventions.

Findings:

Diagnostic tests confirmed neuromyelitis optica.
The patient's relapsing-remitting course was typical for the disease.
Treatment strategies were implemented based on diagnostic findings.

Implications:

Highlights the importance of recognizing neuromyelitis optica in young patients.
Emphasizes the need for accurate diagnostic tools to differentiate from multiple sclerosis.
Informs clinical practice regarding management of this rare neuroinflammatory disease.